New publication in DNA assembly method:

Single 3′-exonuclease-based multifragment DNA assembly method (SENAX). Scientific reports

New publication in Thermogenetics:

Highly Reversible Tunable Thermal-Repressible Split-T7 RNA Polymerases (Thermal-T7RNAPs) for Dynamic Gene Regulation. ACS Synthetic Biology

State of the art in Thermogenetics:

Thermogenetics: Applications come of age. Biotechnology advances

Trends in DNA data storage:

Novel modalities in DNA data storage. Trends in Biotechnology

Biodesign based on engineering principles

At the NUS Engineering Biology Lab, we apply engineering principles to design and build microbes with useful capabilities for medical and industrial applications, developing foundational platform tools to accelerate the design and engineering of the microbes.

Optogenetics

We aim to control bacterial behavior with high spatial and temporal resolution using electromagnetic signals.

Biosensors

We aim to develop biosensors that, incorporated into our engineered cells, allow them to react to different external stimuli.

Modeling and software tools

We aim to develop computational tools to reproduce cell behavior to make engineering-based biode.

Biomanufacturing

We aim to engineer microbial cell factories that enable production of value-added chemicals and proteins.

Biofilm engineering

We aim to control biofilm development in order to obtain scalable, cost-effective bioproduction systems.

Diagnostics and Therapeutics

We aim to use engineered bacteria to fight potentially deadly infectious diseases such as cholera.

The Engineering Biology Lab at NUS focuses on Synthetic Biology to address challenges in different areas including healthcare and environment. We apply engineering principles to design and build microbes with useful capabilities for medical and industrial applications and developing foundational platform tools to accelerate the design and engineering of the microbes. This includes synthetic gene circuits design and automation, modelling of biological systems, and computer aided design tools for SynBio. We have been “reprogramming” microbes to tackle metabolic diseases, to fight infectious causing pathogen and to control biofilm formation. Our motivation is to make engineering of biology more efficient and predictive so that we can scale complexity in order to create novel solutions to tackle global challenges.